GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs1061377 | 1 | rs4974998 | chr4:39110749 | KLHL5 | chr4:39046659-39123828:+ | -0.21 | -5.78 | 1.38E-8 | Uric acid levels |
| THCA | cis | rs7655841 | 1 | rs4975193 | chr4:129980630 | C4orf33 | chr4:130014829-130033842:+ | -0.6 | -9.44 | 1.71E-19 | Chronic obstructive pulmonary disease (moderate to severe) |
| THCA | cis | rs7655841 | 1 | rs4975194 | chr4:129982377 | C4orf33 | chr4:130014829-130033842:+ | -0.6 | -9.44 | 1.71E-19 | Chronic obstructive pulmonary disease (moderate to severe) |
| THCA | cis | rs7069346 | 1 | rs4980171 | chr10:124743200 | C10orf88 | chr10:124690419-124713919:- | -0.23 | -4.27 | 2.36E-5 | Migraine without aura |
| THCA | cis | rs7069346 | 1 | rs4980239 | chr10:124741184 | C10orf88 | chr10:124690419-124713919:- | -0.22 | -4.08 | 5.37E-5 | Migraine without aura |
| THCA | cis | rs4982731 | 1 | rs4982731 | chr14:23585333 | C14orf119 | chr14:23564788-23569664:+ | 0.15 | 3.61 | 0.000343 | Acute lymphoblastic leukemia (childhood) |
| THCA | cis | rs4982731 | 1 | rs4982731 | chr14:23585333 | CDH24 | chr14:23516271-23526747:- | 0.16 | 3.74 | 0.00021 | Acute lymphoblastic leukemia (childhood) |
| THCA | cis | rs7200543 | 1 | rs4985124 | chr16:15125441 | NTAN1 | chr16:15131717-15149833:- | 0.15 | 4.28 | 2.22E-5 | Metabolic traits;Glycerophospholipid levels |
| THCA | cis | rs7200543 | 1 | rs4985124 | chr16:15125441 | PDXDC1 | chr16:15068599-15233195:+ | 0.33 | 7.6 | 1.56E-13 | Metabolic traits;Glycerophospholipid levels |
| THCA | cis | rs7200543 | 1 | rs4985154 | chr16:15131642 | NTAN1 | chr16:15131717-15149833:- | 0.13 | 3.93 | 9.87E-5 | Metabolic traits;Glycerophospholipid levels |
| THCA | cis | rs7200543 | 1 | rs4985154 | chr16:15131642 | PDXDC1 | chr16:15068599-15233195:+ | 0.33 | 7.74 | 6.14E-14 | Metabolic traits;Glycerophospholipid levels |
| THCA | cis | rs6499255 | 1 | rs4985518 | chr16:69787158 | COG4 | chr16:70514473-70557457:- | -0.19 | -3.88 | 0.000118 | IgE levels |
| THCA | cis | rs6499255 | 1 | rs4985523 | chr16:69797192 | COG4 | chr16:70514473-70557457:- | -0.18 | -3.62 | 0.000332 | IgE levels |
| THCA | cis | rs7226229 | 1 | rs4985813 | chr17:20901001 | USP22 | chr17:20902908-20947073:- | -0.17 | -3.61 | 0.000342 | Blood trace element (Se levels) |
| THCA | cis | rs7226229 | 1 | rs4985820 | chr17:20931660 | USP22 | chr17:20902908-20947073:- | -0.18 | -3.75 | 0.0002 | Blood trace element (Se levels) |